I'm also running zencart with Mosso as a host and having nearly the same problem. Instead of a new window opening with the above error, I just get taken to a file not found page. I've tried all the suggestions up to and including the cwd.php and had the same results. I'd like to try the last suggestion that seemed to work for lamont, but apparently I have a lot less experience than lamont has, because I'm a bit confused. Is there a tutorial that describes step-by-step how to accomplish setting up the site manually, running the database using phpMyAdmin, and editing the config files? I apologize in advance for being a hopeless newb.