Hi Hitch,
-with "odd things" you mean it's totally random? Or is it always related to prices or descriptions or ...?
-Is it possible to reproduce the problem with just one (or a couple) of product(s)?
Every time when you click the Update button Quick updates sends two POST arrays: quick_updates_new (contains the form input values the admin may update) and quick_updates_old (from hidden form inputs that hold the original values) and compares their values to determine if anything needs to be updated or not. If you know how, you can compare those arrays to see if their values are correct.
edit:
@francocauter: you have posted your question in the wrong place, this thread is about quick updates only.