Scenario:
A product is $100 and quantity discount for 4+ is $80 for normal customers.
Wholesale Group A is charged $50 for same product. If the wholesale Group A customer purchases less than 4 he is charged $50 but if he purchases 4 or more he is charged $80.
I have to try that out to see what happens. My first thought is that buying that way would conflict with both these modules as these are setting flat prices for a given group of purchasers.

Obviously you can do a workaround (which I actually do but for a different reason) by creating a "special" which is a pre-pack at a reduced price. You then cross-sell it so even if the person bypasses the product listing they still see it cross-sold on the product page before ordering.

I use it as an upsell technique since I know most buyers buy say "3" and so I run a special at "5" units to get the upsell. It works really well in my case anyway.