I get the following error message. Can anyone help?

[FONT=Verdana][FONT=arial,helvetica,sans-serif] PHP Warning: require_once(/home/virtual/companydomain.com/var/www/html/includes/configure.php) [<a href='function.require-once'>function.require-once</a>]: failed to open stream: No such file or directory in /var/www/html/currency_update.php on line 21

PHP Fatal error: require_once() [<a href='function.require'>function.require</a>]: Failed opening required '/home/virtual/[/FONT][/FONT][FONT=Verdana][FONT=arial,helvetica,sans-serif]companydomain.com[/FONT][/FONT][FONT=Verdana][FONT=arial,helvetica,sans-serif].com/var/www/html/includes/configure.php' (include_path='.:/php/includes:/usr/share/php') in /var/www/html/currency_update.php on line 21[/FONT][/FONT]
[FONT=Verdana][FONT=arial,helvetica,sans-serif][/FONT][/FONT]