There is normally no need to change any of the sessions settings unless your hosting environment requires it (which is seldom).
The only common exception would be the "recreate session" option which most PHP5 installations have a problem with, at least prior to v1.3.0.2 where a hack was implemented to work around a php5 bug.
The defaults are:
Code:
Cookie Domain True
Force Cookie Use False
Check SSL Session ID False
Check User Agent False
Check IP Address False
Prevent Spider Sessions True
Recreate Session True
IP to Host Conversion Status true