I have had reason to edit my configure.php files on several occasions, (different installs of zencart), and whenever I edit the file, ftp to the server and go to main page of zencart, I get the page which tells me (I forget exactly) that it is first time,a nd I need to go through the install process, reinstall the install directory, etc. Happens when, for example, I change localhost to domain name, but on any occasion I change the file/s.