Well, kind of depends on what you consider a problem... Caching is used to speed up access to the site. So no caching, slower speed... Impacts visitors experience... It could have been the issue, and if caching being disabled seems to fix that then correcting the caching might also fix that. (Such a process is already in place in. ZC 1.5.3 and above)
The other part to that could be information in the includes/configure.php where DIR_FS_CACHE is defined and there is a setting just above that indicating where to cache things, none, db, or file. As well, the permissions of the directory referenced by the above constant...
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