May have to read this response a few times.
EP4 or any variation of such does not itself offer catalog side control of options. It interacts with the database to provide information (on import) to populate the database information. If there is a plugin that uses such data to control customer selection, then in that case the data imported will affect the customer's ability to select the product's attributes.
Such a plugin may be Stock By Attributes, available from https://github.com/mc12345678/Stock_...butes_Combined
Using that plugin (or a similar commercial option) it is possible to indicate what attribute(s) become available based on selection of a previous attribute. In that regards, this plugin does support stocking attribute variants that are already defined. This population is currently supported for SBA. It is unknown if other such modules are supported as they have not been tested by me nor reported by others as supported.
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