That seems a very straightforward design to implement in Zen Cart. (No doubt you'll hit a few gotchas, but persevere!)
Start by finding a template in the downloads area that gets you moving in the right direction. Then have a close look at it using Firebug and other tools to analyze its layout. Generally you'll be looking for a 2- or 3-column layout with a top logo area that either spans the whole width or is only over the center main column -- your choice.
Then chop up your graphics so the top logo area can be put into the logo area of the template, and any other key graphics are cut to size for their locations. Assume any text -- other than a major title or sub-title -- will be rendered by the browser and is largely out of your control. (What I mean is that you can't assume your web site visitor will have the font Uber-delicate sans MS on their machine, so it may get replaced by, heaven help us, Helvetica! But that's no excuse to try to use pictures of text instead.)
In the admin area of ZC turn off the right column (most templates have it on by default.) Input your text. (That short sentence can cover days of work setting up categories and products and descriptions. :lamo: )
Don't forget the settings in the language files so that standard site text comes out right. Upload your product images in the usual three sizes.
Did I mention OVERRIDES? Read about the override system and use it. Really. You'll be glad you did.
I've probably forgotten many things, but that's what the forum is for ... and the FAQ ... and the wiki ... and the tutorials.
That's a good looking design. You can do it. I look forward to seeing it as a ZC site.
Rob